Kindeva Drug Delivery (Kindeva), a global leader in drug-device combination products, today announced its investment in a second manufacturing line for the production of pressurized metered-dose inhaler (pMDI) products containing low-GWP (Global Warming Potential) propellants in its Loughborough, U.K., facility.
This new line will be capable of handling both HFA-152a and HFO-1234ze propellants — that have a GWP of 90% and 99.9% lower than the industry standard HFA-134a, respectively — and is anticipated to be operational in 2026. Kindeva’s first pMDI manufacturing line, which was announced in 2022 , is in its installation phase and will be completed later in 2024.
Milton Boyer , Kindeva’s CEO said: “This investment will bring to the market one of the first large-volume commercial green propellant lines to the contract manufacturing market capable of supplying up to 50 million pMDI units per year. This second investment in low-GWP GMP manufacturing capacity further underscores Kindeva’s commitment to enable the pharmaceutical industry to meet its sustainability goals, whilst ensuring patient choice is not compromised. With our first GMP low-GWP manufacturing line expected to be operational in 2024, we are proud to be leading the transition to low-GWP propellants by ensuring the capacity is available.”
The new manufacturing line meets an increased customer demand for more sustainable pMDI products and considers the recent adoption of F-gas legislation in the European Union. Phase down of the existing propellants will commence in 2027 in the EU and be completed by the end of 2029.
Boyer continued: “With a track record of nearly 70 years in pMDIs — including the invention of the pMDI in 1956 and leading the CFC- to HFA-inhaler transition in the 1990s — we are excited to be a part of this industry-wide switch in the pMDI space. Kindeva is doing everything we can to ensure a greener future for all stakeholders by doubling down on our commitment to the low-GWP evolution.”
This announcement marks a continuation in the next chapter of Kindeva’s leadership in driving sustainable innovation in pMDIs and, more broadly, complex drug and combination products.
About Kindeva Drug Delivery
Kindeva Drug Delivery is a global contract development and manufacturing organization focused on drug-device combination products. We develop and manufacture products across a broad range of drug-delivery formats, including pulmonary & nasal, injectable, and transdermal. Our service offerings span early-stage feasibility through commercial scale drug product fill-finish, container closure system manufacturing, and drug-device product assembly. Kindeva serves a global client base from our state-of-the-art manufacturing, research, and development facilities located across the U.S. and U.K.
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Lindsey Langemeier
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