American depositary receipts of Asian stocks were 0.6% lower at 1,924.75 on the S&P/BNY Mellon Asia 50 ADR Index Wednesday.
In North Asia, the gainers were led by mobile health care platform 111 (YI) and software provider Aurora Mobile (JG), which rose 5.9% and 3.6% respectively. They were followed by video-sharing service Bilibili (BILI) and So-Young International (SY), an online platform for medical aesthetics, which were up 2.8% and 1%.
The decliners in North Asia were led by wealth management firm Noah (NOAH) and mobile app developer Cheetah Mobile (CMCM), which fell 14% and 4.4% respectively. They were followed by educational services provider Rise Education Cayman (REDU) and online personal finance platform Jiayin Group (JFIN), which lost 4.1% and 3.7%.
In South Asia, the only gainers were telecom operator PLDT (PHI) and bank holding company ICICI Bank (IBN), which were up 2.4% and 1% respectively.
The heaviest decliner in South Asia was the IT firm Infosys (INFY), which lost 1.8%, followed by biotech Aslan Pharmaceuticals (ASLN) and automaker Tata Motors (TTM), which dropped 1.2% each. IT contractor Wipro (WIT) was off 0.9%.